The Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument on board the Thermosphere Ionosphere Mesosphere Energetics and Dynamics satellite has been measuring radiances for more than 15 years with nearly a global coverage. These measurements allowed simultaneous retrieval of CO2 VMR and temperature vertical profiles, along with consistently calculated cooling/heating rates. We investigate the coupling between the long-term trends in the Thermosphere-Ionosphere (T-I) (as captured by several ionospheric indicators) and spatial distributions of long-term trends of green-house gases in the MLT region. The CO2 long-term changes in the MLT are believed to be stable, reflecting the tropospheric trends, as there are no sources of carbon within the upper atmosphere, and it can act as a forcing on the local thermal field. First, we analyze whether the derived products are consistent with each other, and how they compare with other similar datasets. Then, the spatial and temporal variability for each of the parameters covering period (2002-2016) is quantified in order to better understand the CO2 coupling with the T-I region, known to undergo a long term contraction. Although the T-I is known to be strongly coupled system with the lower atmosphere, resolving the long term behavior of CO2, its spatial distribution and solar energy input response is important step disentangling the individual components driving the changes of this atmospheric region.