Ozone has significant contribution in changing the radiative forcing and temperature in the lower and middle atmosphere by trapping outgoing long wave radiation at 9.6 μm. Thus, it is very important to study the ozone vertical variability and transport mechanism in both stratosphere and troposphere. It has been shown that ozone loss leading to stratospheric cooling and hence changes in the circulation. However, recent studies revealed that the ozone recovery started and is expected to be at the same levels as that of 1980’s by 2050. In the present context we have given special emphasise to investigate ozone, water vapour and temperature long-long trends in a changing climate in the upper troposphere and lower stratosphere (UTLS) region over Indian sub-continent For this we have used multi satellite (Upper Atmosphere Research Satellite (UARS, 1992 – 2005)), (Aura Microwave Limb Sounder (MLS, 2004-2015), Sounding of the Atmosphere using Broadband Emission Radiometry (SABER, 2002-2015) on board TIMED (Thermosphere Ionosphere Mesosphere Energetics Dynamics) observations. The long-term trends observed from these satellite observations has been further confirmed using the long-term ground based ozonesonde observations available from the three Indian stations (Delhi, Pune, and Trivandrum) for a period of 1969 – 2015. In general, ozone minimum and maximum is observed in the upper troposphere and lower stratosphere, respectively. Initial results revealed a significant raise in the altitude of ozone minima when compared to that observed during 1980’s in the upper troposphere. The altitude of ozone maximum also show increasing trend in recent decade compared to 1980’s.