The response other ionized chemical species in the lower ionosphere (D-region) to solar cycle in UV have been simulated with 3D global photochemical transport model CHARM-I (CHemical Atmospheric Research Model with Ions), developed at the Laboratory for Atmospheric Chemistry and Dynamics at Central Aerological Observatory [1]. Model describes the interaction between 70 neutral and ionized chemical species involved in 200 photochemical reactions. “Family” technique was used for solving kinetic part of equations for neutrals and the algorithm which controls total electroneutrality was realized for ions. Prather’s scheme was used to describe advection. 3D global temperature wind components fields (daily averaged) calculated by GCM ARM (Atmospheric Research Model [2]) were used in simulations. Solar cycle signal in UV solar irradiance measured from space (SIM and other instruments) has been introduced in the model. Ionization was induced by Lα and GCRs. The results obtained by simulations revealed global changes in electron density and of other ions (no more than 20%) in phase with solar cycle in the mesosphere. Limited response induced by GCRs was found also in the lower stratosphere. This work was supported by Russian Science Foundation for Basic Research (grant N 13-05-0105213). [1] A.A. Krivolutsky, L.A. Cherepanova, T. Yu. V’yushkova, A.I. Repnev, The Three-dimensional global numerical model CHARM-I: The Incorporation of Processes of Ionospheric D-region, vol. 55, N 4, 483-503, 2015. [2] A.A. Krivolutsky, L.A. Cherepanova, A.V. Dement’eva, A.I. Repnev, and A.V. Klyuchnikova. Global circulation of the Earth’s atmosphere between 0-135 km calculated with the ARM model. Consideration of the solar activity contribution. Geomagnetism and Aeronomy, vol. 55, N 6, 808-828, 2015.