During the past two decade, significant advancement has been made to understand the long term trends caused due to anthropogenic activities and that of natural variability in the whole atmosphere from ground to thermosphere. A global picture of the temperature response to GHGs increase and solar activity in the mesosphere and lower thermospheric regoin is presented with respect to geography, period of analysis and seasons. The discrepancy in the solar signal of temperature obtained by experimental data and the model results over the equatorial regions is still unresolved. In this talk, an update of the long-term trend and solar signal in temperature of the MLT-region has been made based. The question of break in trend as a result of ozone recovery is briefly touched upon. However, now the major challenge is in the interpretation of the various reported results which are diverse and even indicates latitudinal variability.